Although the well-known autosomal dominant gene mutations for Familial Hypercholesterolemia are LDLR, APOB, and PCSK9, there are lesser-known recessive mutations that can result in elevated cholesterol levels. One of these recessive gene mutations is LDLRAP1, but THIS ARTICLE describes a…
I often say, “I do all the same things I did when I was 20… I’m just worse at them and I hurt more afterwards.” But given that people with the highest cardiorespiratory fitness tend to have the lowest risk…
France has contributed many luminaries to science, including Pascal and Descartes, but maybe Metformin, a glucose-lowering medication taken by millions of people, deserves a place on this proverbial intellectual Mont Blanc as well. Derived from the French lilac, Metformin continues…
Healthcare professionals in metabolic clinics have all been subject to the ironic situations in which people with type 2 diabetes INSIST that drinking Diet Soda will instantly kill them and simultaneously plunge the world into nuclear conflict. Meanwhile, their Continuous…
The punch line to the joke, “Why did the PCSK9 inhibitor not work?” is usually, “Because the patient never took it!” But occasionally, people will get a less-than-expected response in LDL-C lowering to PCSK9 inhibitors. This is quite unusual, but…
PCSK9 is well-known for its role in cholesterol homeostasis, and most are aware that PCSK9 targets the LDL receptor for lysosomal degradation. Given that the LDL receptor in the liver is what clears the majority of ApoB cholesterol-laden particles from…
So I’m opening a HUGE CAN OF WORMS here, but hopefully in doing so I’ll “bait” you into reading subsequent posts…breaching the topic of Fish Oil is a Deep Dive into some confusingly murky waters! But for a little bit…
In the category of “Interesting and Very Likely to Cause People to Overreact and Leap to Conclusions,” this new article showed an association between medications that inhibit cholesterol synthesis when used during pregnancy and a diagnosis of autism. In a…
Every now and then, an article like this one about a possible association between air pollution and cardiovascular disease pops up…and it reminds me of a magical Millennial memory from childhood cartoons…Captain Planet and the Planeteers! A green-haired hero with…
In the middle of this recent article on ketogenic diets and blood cholesterol levels, the recently discovered hormone cholesin was mentioned. (This article speculated that those on a ketogenic diet experience an increased degree of intestinal cholesterol absorption, which I…
