Many of you have heard me rap about Cholesterol and Cardiovascular Disease at various conferences and meetings (and stay tuned for my current work-in-progress, which is a “Guidelines Paradise” that pays homage to both Coolio and the 2026 Cholesterol Guidelines…
There has recently been much hullabaloo about THIS ARTICLE suggesting that ezetimibe, a cholesterol absorption inhibitor, may have some protective effects against Alzheimer’s Disease, which I believe is ultimately a metabolic and lipid disorder (Check out this Podcast episode where…
“Vulnerable Coronary Plaque” is the topic of today’s discussion, and what we have observed in a meta-analysis of 17 different invasive intravascular ultrasound (IVUS) studies is that every 1% reduction in percent atheroma volume (PAV), which is a measure of…
“Anyone who says that God never gives you something you can’t handle has never been completely shattered. God DOES give us things that are way too much for us to handle, but it’s during those times we learn to trust…
Some friends and I were discussing ApoE today (since this is what “normal” people do to unwind on Saturdays), and since a recently published article revealed a new ApoE isoform called ApoE2 WOLVERINE (cue the “Hugh Jackman gets his lipids…
It’s been quite a week for news about the Felons of the Lipid Neighborhood, (which you can read more about in Chapter 6 of THIS BOOK) and since we all know the news can be pretty depressing, I’ll get back…
It has been well-recognized that having too many Lp(a) “Felons” in your Lipid Neighborhood is associated with increased risk of heart attacks and calcific aortic stenosis (among other things), but a recent study of over 66,000 US adults with Lp(a)…
An intriguing new CCTA study called the Essence-TIMI 73b (which sounds like part of the Complement Cascade from Immunology class) was presented of Olezarsen (Tryngolza), an ApoC3 inhibitor currently approved for Familial Chylomicronemia (which, to this point, has shown impressive…
Today is Lp(a) Awareness Day, and I refer to this genetic risk factor as “The Felon of the Lipid Neighborhood” in Chapter 6 of my book. And one of my best friends is a great example of how nefarious Lp(a)…
“Elevated insulin, impaired fasting glucose, prediabetes, diabetes…they’re all the same problem of insulin resistance. It’s like being almost pregnant…you either are or you aren’t. It’s just a matter of how far along you are in the process.” Casey Ruff is…
