The punch line to the joke, “Why did the PCSK9 inhibitor not work?” is usually, “Because the patient never took it!” But occasionally, people will get a less-than-expected response in LDL-C lowering to PCSK9 inhibitors. This is quite unusual, but…
PCSK9 is well-known for its role in cholesterol homeostasis, and most are aware that PCSK9 targets the LDL receptor for lysosomal degradation. Given that the LDL receptor in the liver is what clears the majority of ApoB cholesterol-laden particles from…
So I’m opening a HUGE CAN OF WORMS here, but hopefully in doing so I’ll “bait” you into reading subsequent posts…breaching the topic of Fish Oil is a Deep Dive into some confusingly murky waters! But for a little bit…
In the category of “Interesting and Very Likely to Cause People to Overreact and Leap to Conclusions,” this new article showed an association between medications that inhibit cholesterol synthesis when used during pregnancy and a diagnosis of autism. In a…
Every now and then, an article like this one about a possible association between air pollution and cardiovascular disease pops up…and it reminds me of a magical Millennial memory from childhood cartoons…Captain Planet and the Planeteers! A green-haired hero with…
In the middle of this recent article on ketogenic diets and blood cholesterol levels, the recently discovered hormone cholesin was mentioned. (This article speculated that those on a ketogenic diet experience an increased degree of intestinal cholesterol absorption, which I…
Yesterday, we witnessed some ABSOLUTELY SUPERHUMAN performances by Sebastian Sawe and Yomif Kejelcha, as both men RAN SUB-2 HOURS at the London Marathon. And to put this in perspective (and with the Disclaimer that “Nothing I say is Medical Advice”)…
“This girl is on FIBER!” -Alicia Keys, Metamucil Remix Edition “Eat more fiber” is often hailed as a dietary axiom…but fiber is actually a rather complicated topic. Because there is insoluble and soluble fiber…and then there are viscous and non-viscous…
I actually don’t get bloodwork for myself very often (I prefer to help others with their labs), but recently I obtained a fasting Cholesterol Panel. And sometimes getting bloodwork is a good opportunity to discuss what each of these things…
Sometimes when a new set of Cholesterol Guidelines is released, you have to parody an iconic Coolio song and put the roughly 948 pages of the document into a more digestible hip-hop format. And rumor has it there is a…
