Sometimes when a new set of Cholesterol Guidelines is released, you have to parody an iconic Coolio song and put the roughly 948 pages of the document into a more digestible hip-hop format. And rumor has it there is a live performance of this out there somewhere…who knows? But below are the lyrics:

Guidelines Paradise featuring L.P. Lil’ Jay

The New Lipid Guidelines sit right here on my desk

And as I start to read, I take a giant breath

Cuz I’ve been preaching this stuff for so long I

Don’t think I can take it if they get this one wrong

They’ve decided risk extends beyond just year 10

PCE is in the trash and now they’re lauding PREVENT, fool

So now you can use another risk score

Or maybe use a CAC to say a patient needs more

So Friedewald is out and Martin-Hopkins is in

But not checking ApoB is really a sin

And make sure you get an Lp(a) at least one time

And to calculate non-HDL don’t even cost a dime

Chorus:

We’ve been spending most our lives

Using old Cholesterol Guidelines

Exposure over time

In these new Cholesterol Guidelines

Target less than 55

In these new Cholesterol Guidelines

Your prior auth might work this time

With the new Cholesterol Guidelines

Verse 2

My patient says statins made his muscles weak

But we’ve got other ways to reduce his ApoB

Even if he’s high risk I think he’ll be fine

Cuz we’ve got even more tools beyond ezetimibe

And it’s more than just lipids when talking risk

Inflammation and South Asian are on the list, fool

CKM and gestation and UACR

You gotta use your brain to really save the heart

CLEAR-OUTCOMES, FOURIER, ESSENCE and PREVENT

We’ve got data and the tools to not have an event

And with FH or PAD or if your CAC’s 300

Don’t wait to get worse, just DO SOMETHIN’

Pre-chorus

Primordial prevention, even kids have fatty streaks

Should we just mix some Lipitor in with your fruit smoothie?

Chorus

We’ve been spending most our lives

Using old Cholesterol Guidelines

Exposure over time

In these new Cholesterol Guidelines

Target less than 55

In these new Cholesterol Guidelines

Your prior auth might work this time

With the new Cholesterol Guidelines

Verse 3

Think you’re pretty fit, maybe you’re a runner

Get your CAC of zero, in 5 years get another

But if when you’re bleeding it kinda looks like butter

Take a medication, then probably add another

A1c and CKD and all the risk enhancers

Understand it, know your numbers, then you got a chance

To never ever have a stroke or heart attack

What the LDL you waitin’ for?  And go get a CAC

Final Chorus

Let’s all shift the paradigm

With the new Cholesterol Guidelines

Like Lizzo said, it’s about time

That we got some new lipid guidelines

Don’t worry ‘bout Jeffrey Epstein

Just read the new Cholesterol Guidelines

Will insurance ever realize

We’ve got new Cholesterol Guidelines?