Category Lipids

The Testo Manifesto

This NEW ARTICLE about “off-label” testosterone prescription and risk of cardiovascular events has been making the headlines largely buried beneath the litany of ads telling guys that their total testosterone of 650 “isn’t high enough.” And although it was a…

The Structure of PCSK9? It’s Tricky! LIPID NERD ALERT!!!

It’s tricky With drug design To stop the PCSK9 It’s tricky! (Tricky, tricky, tricky)! –Rumored Lipid Remix of Run DMC’s iconic hit “It’s Tricky”  Unpublished data suggests that Lipid Learning is enhanced when disseminated in hip-hop format, and I’ve been…

A New Era for PCSK9 Inhibition!

Today’s big news in Lipid Land is that the first oral PCSK9 inhibitor was approved by the FDA!  The generic name of this agent, which mechanistically is a macrocyclic peptide, is enlicitide, and I prefer to stick with that since…

Statins, CoQ10, and Astrocytes: Big-Time LIPID NERD ALERT!

Historically, I haven’t been too enthused about CoQ10 as a supplement given the underwhelming trials and mixed results in abrogating drug-associated muscle symptoms in those on statins. I think creatine supplementation is a much more compelling option, and I think…

Plaque Rats and Prevention

Rats have been responsible for various plagues and pestilences throughout human history, and given their fecundity and ubiquity, they are nowhere near the Endangered Species list…except for one place on the planet: the Canadian province of Alberta. But it’s not…