Josh W

Josh W

A New Era for PCSK9 Inhibition!

Today’s big news in Lipid Land is that the first oral PCSK9 inhibitor was approved by the FDA!  The generic name of this agent, which mechanistically is a macrocyclic peptide, is enlicitide, and I prefer to stick with that since…

On the Brink of a Wordle War

We live in a United States that is anything but united on so many topics. Pontifications over Politics. Conflicts over Cholesterol. Squabbles over Censorship…and of course, the G.O.A.T debates of Jordan vs LeBron vs Kobe.  But I didn’t anticipate the…

Leaving Better Off

Are you better off now because you met me? Did I truly listen in your time of need? I cannot lie, I spoke truth, of course But how was it uttered?  With grace or blunt force? Did I just talk,…

Take Me Back to 2006, Larry-Boy!

20 years ago, we lived in a much different world. We somewhat-legally downloaded music and burned CDs on a near-nightly basis. We looked forward to the release of Pirates of the Caribbean…on DVD!  Shakira taught us the importance of Honest…

Statins, CoQ10, and Astrocytes: Big-Time LIPID NERD ALERT!

Historically, I haven’t been too enthused about CoQ10 as a supplement given the underwhelming trials and mixed results in abrogating drug-associated muscle symptoms in those on statins. I think creatine supplementation is a much more compelling option, and I think…

Disgruntlement and Dodgeball

Very few people know what I really do for work, which is fine…it helps me maintain that “Edgy Mystique,” which, as the kids say, adds to my aura.  And I’m pretty useless at most normal adult tasks, which becomes painfully…

Vacation Bible School…28 Years of Bliss

28 years ago, my parents asked me to help with something called Vacation Bible School.  We had never been on a family vacation, but I was well-acquainted with the Bible and everyone knew I loved school. Additionally, this Vacation Bible…

Dumbus Albacore

Many people are convinced that The Algorithm is watching/stalking us based on our recent Internet browsing activity, and it is pretty eerie that as soon as my wife even considers buying a new dishwasher, we immediately have about 5 ads…