Although the well-known autosomal dominant gene mutations for Familial Hypercholesterolemia are LDLR, APOB, and PCSK9, there are lesser-known recessive mutations that can result in elevated cholesterol levels. One of these recessive gene mutations is LDLRAP1, but THIS ARTICLE describes a…
I often say, “I do all the same things I did when I was 20… I’m just worse at them and I hurt more afterwards.” But given that people with the highest cardiorespiratory fitness tend to have the lowest risk…
France has contributed many luminaries to science, including Pascal and Descartes, but maybe Metformin, a glucose-lowering medication taken by millions of people, deserves a place on this proverbial intellectual Mont Blanc as well. Derived from the French lilac, Metformin continues…
We live in a society of Cellular Self-Destruction and Handheld Hell. We are overstimulated yet vacuous, tired but wired, technologically savvy but socially inept. We have mortgaged happiness for app-iness, always upgrading, but internally deteriorating. Music is always playing, but…
“You can play a lot of basketball in the last 60 seconds.” -Ben Sasse Maybe you think you’re at Halftime of the Game of Life. Maybe you’re still in the first quarter and it would seem like there’s “a lot…
I love birthdays…and holidays…and random Tuesdays…and any day that I can give gifts to people whom I love. The point of giving is not to experience personal blessings…but it’s an ancillary benefit that accompanies unselfish motivations. And when that person…
“Hard times create strong men. Strong men create good times. Good times create weak men. And, weak men create hard times.” -G. Michael Hopf, Those Who Remain We live in an interesting era in which people will spend more time…
Healthcare professionals in metabolic clinics have all been subject to the ironic situations in which people with type 2 diabetes INSIST that drinking Diet Soda will instantly kill them and simultaneously plunge the world into nuclear conflict. Meanwhile, their Continuous…
This picture was taken about 30 years ago…I was just emerging from my blonde bowl-cut era and preparing to embark on a new journey of Maximum Hold Hair Gel. But despite my questionable haircut preferences, I wouldn’t have traded my…
The punch line to the joke, “Why did the PCSK9 inhibitor not work?” is usually, “Because the patient never took it!” But occasionally, people will get a less-than-expected response in LDL-C lowering to PCSK9 inhibitors. This is quite unusual, but…
